Inside each human cell, about 2 meters (6.6 feet) of genomic DNA must be accurately copied and equally transmitted to two daughter cells during cell division. To achieve this, the copied DNA is condensed into thick, short structures called mitotic chromosomes. However, how chromatin is organized and condensed to form mitotic chromosomes has long remained a major question in genetics and cell biology.

Inside each human cell, about 2 meters (6.6 feet) of genomic DNA must be accurately copied and equally transmitted to two daughter cells during cell division. To achieve this, the copied DNA is condensed into thick, short structures called mitotic chromosomes. However, how chromatin is organized and condensed to form mitotic chromosomes has long remained a major question in genetics and cell biology.

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