Kinesin is a molecular motor responsible for hauling essential cargoes within cells by walking step by step along filamentous tracks known as microtubules. To move efficiently and avoid falling off, the motor’s two feet must coordinate their stepping in a precise direction. Scientists have known that a connecting segment called the neck region is crucial for coordinating this motion. However, its exact three-dimensional structure and how it physically interacts with the microtubule track have remained a mystery because of the limitations of current imaging techniques.

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