A new study tracking thousands of B cells across more than 100 germinal centers in mice reveals how the system consistently produces highly effective antibodies. The findings overturn longstanding ideas about how germinal centers function, revealing that they are far more selective than once thought, and challenges the idea that antibody improvement is driven mainly by rare growth "bursts" among the most successful B cells.

A new study tracking thousands of B cells across more than 100 germinal centers in mice reveals how the system consistently produces highly effective antibodies. The findings overturn longstanding ideas about how germinal centers function, revealing that they are far more selective than once thought, and challenges the idea that antibody improvement is driven mainly by rare growth “bursts” among the most successful B cells.

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