Scientists from Skoltech and the University of Potsdam have developed a physical theory that sheds light on how molecular motors organize the three-dimensional structure of the genome. Using theoretical polymer physics and computer simulations, the researchers for the first time calculated a universal parameter of this organization—the density of loops formed through active extrusion by cohesin motors in each living cell.

Scientists from Skoltech and the University of Potsdam have developed a physical theory that sheds light on how molecular motors organize the three-dimensional structure of the genome. Using theoretical polymer physics and computer simulations, the researchers for the first time calculated a universal parameter of this organization—the density of loops formed through active extrusion by cohesin motors in each living cell.

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