Weill Cornell Medicine researchers have found that temporarily disabling a protein complex that organizes DNA into loops inside the cell's nucleus drastically disrupted the three-dimensional structure of the genome, but surprisingly, most genes continued to function as usual. However, they also discovered a small group of affected genes that play a critical role in guiding cells to become specific types, for example, heart, brain, or liver cells.

Weill Cornell Medicine researchers have found that temporarily disabling a protein complex that organizes DNA into loops inside the cell’s nucleus drastically disrupted the three-dimensional structure of the genome, but surprisingly, most genes continued to function as usual. However, they also discovered a small group of affected genes that play a critical role in guiding cells to become specific types, for example, heart, brain, or liver cells.

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