Cell cultures—single layers of cells grown in a small dish—have enabled researchers to study biological growth, develop or test drugs and even discover what causes some diseases. Cell spheroids, 3D versions of cell cultures built using a process known as cell aggregation, are the next step in advancing this work, capable of more closely modeling real tissue. A new technology, invented by researchers from Penn State and detailed in a paper published in Advanced Science, could breathe fresh air into bottom-up tissue fabrication and potentially large-scale tissue engineering by addressing these issues.

Cell cultures—single layers of cells grown in a small dish—have enabled researchers to study biological growth, develop or test drugs and even discover what causes some diseases. Cell spheroids, 3D versions of cell cultures built using a process known as cell aggregation, are the next step in advancing this work, capable of more closely modeling real tissue. A new technology, invented by researchers from Penn State and detailed in a paper published in Advanced Science, could breathe fresh air into bottom-up tissue fabrication and potentially large-scale tissue engineering by addressing these issues.

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