Some genetic mutations that are expected to completely stop a gene from working surprisingly cause only mild or even no symptoms. Researchers in previous studies have discovered one reason why: cells can ramp up the activity of other genes that perform similar functions to make up for the loss of an important gene's function. A new study from the lab of Whitehead Institute Member Jonathan Weissman now reveals insights into how cells can coordinate this compensation response. The findings are published in the journal Science.

Some genetic mutations that are expected to completely stop a gene from working surprisingly cause only mild or even no symptoms. Researchers in previous studies have discovered one reason why: cells can ramp up the activity of other genes that perform similar functions to make up for the loss of an important gene’s function. A new study from the lab of Whitehead Institute Member Jonathan Weissman now reveals insights into how cells can coordinate this compensation response. The findings are published in the journal Science.

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