Scientists at the Broad Institute and Mass General Brigham have built a generative AI model that creates short DNA segments that can control gene activity in specific cells. These sequences, called cis-regulatory elements (CREs), make up a large part of the human genome, and synthetic versions of these bits of DNA could one day be part of gene therapies that tune gene activity to treat disease.

Scientists at the Broad Institute and Mass General Brigham have built a generative AI model that creates short DNA segments that can control gene activity in specific cells. These sequences, called cis-regulatory elements (CREs), make up a large part of the human genome, and synthetic versions of these bits of DNA could one day be part of gene therapies that tune gene activity to treat disease.

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